Description

8'-Hydroxydihydroergotamine is a key pharmaceutical intermediate and reference standard derived from the ergot alkaloid family. This compound is of significant importance for research and development in the pharmaceutical industry, particularly in the study of migraine therapeutics and receptor pharmacology. It is primarily utilized by pharmaceutical manufacturers, analytical laboratories, and research institutions engaged in drug discovery, quality control, and the synthesis of advanced active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of complex ergot-derived active pharmaceutical ingredients (APIs).
• Analytical Reference Standard: Used in HPLC, LC-MS, and other chromatographic methods for the identification, assay, and impurity profiling of related pharmaceutical compounds.
• Biochemical Research: Valuable tool for studying serotonin (5-HT) receptor binding, vascular pharmacology, and the mechanisms of migraine.
• Quality Control & Method Development: Serves as a certified standard in pharmaceutical QC laboratories to ensure batch-to-batch consistency and regulatory compliance.
• Process Development & Scale-up: Employed in the development and optimization of synthetic routes for pharmaceutical manufacturing.

Basic Information

Product Name	8'-Hydroxydihydroergotamine
CAS No.	90650-44-5
Molecular Formula	C33H37N5O6
Molecular Weight	599.68 g/mol
Synonyms	8'-OH-Dihydroergotamine; 8'-Hydroxy-DHE; 8'-Hydroxy-9,10-dihydroergotamine; (8'R)-8'-Hydroxy-9,10-dihydroergotamine; 8'-Hydroxyergotamine, dihydro-; Dihydro-8'-hydroxyergotamine; 8'-Hydroxy-α-ergocryptine, dihydro- derivative
EINECS	Contact for details

Quality Control

Our 8'-Hydroxydihydroergotamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity determination by HPLC, and control of specific impurities. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing all critical quality attributes to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.