Description

Rizatriptan Benzoate is a selective serotonin receptor agonist, specifically formulated as the benzoate salt of rizatriptan for enhanced pharmaceutical utility. This high-purity active pharmaceutical ingredient (API) is critical for the development of effective migraine and cluster headache treatments. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the formulation of solid oral dosage forms, such as tablets and orally disintegrating tablets.

Application

• Pharmaceutical API: Primary active ingredient in prescription medications for the acute treatment of migraine with or without aura in adults.
• Tablet Formulation: Used in the manufacture of conventional oral tablets and rapidly-dissolving orally disintegrating tablets (ODTs) for quick relief.
• Neurological Research: Serves as a key reference standard and tool compound in preclinical and clinical research focused on serotonin (5-HT1B/1D) receptor pathways.
• Generic Drug Production: Essential for companies developing bioequivalent generic versions of branded migraine therapeutics.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific drug product development.

Basic Information

Product Name	Rizatriptan Benzoate
CAS No.	145202-66-0
Molecular Formula	C22H26N6O2 • C7H6O2
Molecular Weight	532.58 g/mol
Synonyms	Rizatriptan Benzoate; MK-0462 Benzoate; N,N-Dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine Benzoate; 3-[2-(Dimethylamino)ethyl]-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole Benzoate; Maxalt® (brand name salt form); Rizatriptan Monobenzoate
EINECS	Contact for details

Quality Control

Our Rizatriptan Benzoate is manufactured under strict quality management systems. We offer material compliant with current pharmacopeial standards, including USP and EP monographs where applicable. Every batch undergoes comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling. A Certificate of Analysis (COA) detailing all test results is provided with each shipment to ensure full traceability and regulatory compliance for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. The original container should be kept sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.