Description

Naratriptan Hydrochloride CAS NO 143388-64-1 is a selective serotonin (5-HT1B/1D) receptor agonist, a key active pharmaceutical ingredient (API) in the triptan class. It is specifically formulated for the acute treatment of migraine headaches with or without aura in adults, offering a targeted therapeutic approach. This high-purity compound is essential for pharmaceutical manufacturers developing generic and proprietary migraine medications, requiring stringent quality control to ensure efficacy and patient safety.

Application

• Pharmaceutical API: Primary active ingredient in prescription migraine relief tablets.
• Generic Drug Formulation: Core component for the production of bioequivalent generic versions of branded naratriptan medications.
• Clinical Research: Reference standard and raw material for pharmacological studies and new drug development.
• Dosage Form Development: Used in R&D for creating various oral solid dosage forms, including standard and orally disintegrating tablets.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production.

Basic Information

Product Name	Naratriptan Hydrochloride
CAS No.	143388-64-1
Molecular Formula	C17H25N3O2S•HCl
Molecular Weight	371.92 g/mol
Synonyms	Naratriptan HCl; 1-[3-(Dimethylamino)propyl]-N-methyl-1H-indole-5-methanesulfonamide hydrochloride; GR-85548A; N-Methyl-3-(1-methyl-4-piperidinyl)-1H-indole-5-ethanesulfonamide hydrochloride; AMGR-169; Naramig (as formulated product); 5-HT1B/1D agonist
EINECS	Contact for details

Quality Control

Our Naratriptan Hydrochloride is manufactured under strict quality management systems. Each batch is tested to ensure it meets high-purity pharmacopeial standards, with specifications aligned to ICH guidelines. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results for identity, assay, purity, and related substances. We support compliance with cGMP, REACH, and FDA regulatory frameworks for global pharmaceutical supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.