Description

Methysergide Maleate CAS NO 129-49-7 is a synthetic ergot alkaloid derivative and a potent serotonin receptor antagonist. This compound is of significant pharmaceutical importance due to its specific pharmacological activity. It is primarily utilized in research and development for the study of serotonin pathways and the formulation of specialized therapeutic agents.

Application

• Pharmaceutical Research & Development: A key reference standard and active pharmaceutical ingredient (API) intermediate in the investigation of serotonin-related disorders.
• Neurological & Migraine Research: Used in preclinical studies to understand vascular headaches and serotonin's role in the central nervous system.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical laboratories.
• Biochemical Studies: Employed as a tool compound to antagonize specific serotonin (5-HT) receptor subtypes in experimental models.
• Academic Research: Utilized in university and institutional labs for pharmacological and neurochemical research projects.

Basic Information

Product Name	Methysergide Maleate
CAS No.	129-49-7
Molecular Formula	C₂₁H₂₇N₃O₅ • C₄H₄O₄
Molecular Weight	469.51 g/mol
Synonyms	Methysergide hydrogen maleate; 1-Methyl-D-lysergamide hydrogen maleate; Deseril; Sansert; UML-491; (8β)-9,10-Didehydro-N-[1-(hydroxymethyl)propyl]-1,6-dimethylergoline-8-carboxamide (Z)-2-butenedioate; 1-Methylmethylergonovine hydrogen maleate
EINECS	204-944-7

Quality Control

Our Methysergide Maleate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identification by IR and NMR spectroscopy, and residual solvent analysis to ensure it meets high-grade standards for research use. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.