Description

Naratriptan CAS NO 121679-13-8 is a selective serotonin (5-HT1B/1D) receptor agonist belonging to the triptan class of pharmaceuticals. This compound is critical for the effective management of acute migraine headaches by inducing cranial vasoconstriction and inhibiting the release of pro-inflammatory neuropeptides. It is an essential active pharmaceutical ingredient (API) primarily required by pharmaceutical manufacturers and research institutions developing or producing advanced migraine therapeutics.

Application

• Pharmaceutical API: Primary use as the active ingredient in the formulation of prescription migraine medications (tablets).
• Generic Drug Manufacturing: Sourcing for the production of bioequivalent generic versions of branded naratriptan products.
• Clinical Research: Utilization in preclinical and clinical studies for evaluating new migraine treatment protocols or combination therapies.
• Reference Standard: Serves as a high-purity chemical reference standard in analytical laboratories for quality control and method development.
• Drug Development: Intermediate or starting material in the R&D of novel serotonin receptor-targeting compounds.

Basic Information

Product Name	Naratriptan
CAS No.	121679-13-8
Molecular Formula	C17H25N3O2S
Molecular Weight	335.47 g/mol
Synonyms	Naratriptan Hydrochloride; N-Methyl-3-(1-methyl-4-piperidinyl)-1H-indole-5-ethanesulfonamide; GR-85548; Naramig; Amerge; (R)-Naratriptan; 1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
EINECS	Contact for details

Quality Control

Our Naratriptan is manufactured and tested under strict quality management systems. We provide material that meets high-purity standards suitable for pharmaceutical applications, with comprehensive testing for identity, potency, and impurities. Certificates of Analysis (COA) documenting compliance with agreed specifications are provided with each batch.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a low-humidity environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.