Description

Naratriptan CAS NO 112111-49-6 is a selective serotonin receptor agonist belonging to the triptan class of pharmaceuticals. It is a critical active pharmaceutical ingredient (API) specifically developed for the acute treatment of migraine headaches with or without aura. This compound is essential for pharmaceutical manufacturers producing effective migraine relief medications. Its mechanism of action involves constricting cranial blood vessels and blocking pain pathways in the brain.

Application

• Pharmaceutical API: Primary use as the active ingredient in prescription migraine medications.
• Tablet Formulation: Manufacture of oral tablet dosage forms for migraine treatment.
• Clinical Research: Use as a reference standard in pharmacological and pharmacokinetic studies.
• Drug Development: Serves as a key compound in the R&D of new neurological therapeutics.
• Generic Drug Production: Essential for manufacturers producing bioequivalent generic versions of branded naratriptan drugs.

Basic Information

Product Name	Naratriptan
CAS No.	112111-49-6
Molecular Formula	C17H25N3O2S
Molecular Weight	335.46 g/mol
Synonyms	Naratriptan Hydrochloride; N-Methyl-3-(1-methyl-4-piperidinyl)-1H-indole-5-ethanesulfonamide; GR 85548; Naramig; Amerge; 1-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-methylmethanesulfonamide; (R)-2,3-Dihydroxypropyl 5-Amino-2,4,6-Triiodobenzoate (related salt forms may be listed under this CAS).
EINECS	Contact for details

Quality Control

Our Naratriptan is manufactured under strict quality management systems. We provide material that meets or exceeds pharmaceutical-grade specifications, with typical purity levels ≥98.5% (by HPLC). Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, impurity profile, and residual solvents. Our quality protocols are designed to ensure compliance with ICH guidelines and relevant pharmacopeial standards for active pharmaceutical ingredients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a low-humidity environment to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.5% - 101.0% (on anhydrous basis)
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.