Description

Dihydroergotamine Mesylate is a high-purity pharmaceutical active ingredient, a semi-synthetic derivative of ergotamine. It is a potent vasoconstrictor and serotonin receptor agonist, primarily valued for its efficacy in treating acute migraine and cluster headaches. This compound is essential for pharmaceutical manufacturers developing injectable and nasal spray formulations, as well as for research institutions conducting neurological and cardiovascular studies.

Application

• Pharmaceutical Manufacturing: Primary active ingredient in injectable solutions and nasal sprays for acute migraine therapy.
• Neurological Research: Used as a reference standard and experimental compound in studies of serotonin (5-HT) receptors and vascular headaches.
• Analytical Chemistry: Serves as a certified reference material (CRM) for HPLC and LC-MS method development and validation in quality control labs.
• Drug Development: Key intermediate or active pharmaceutical ingredient (API) in the R&D of new migraine and neurovascular medications.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of finished dosage forms.
• Regulatory Submissions: Used to generate data for Drug Master Files (DMFs), ANDAs, and other regulatory compliance documentation.

Basic Information

Product Name	Dihydroergotamine Mesylate
CAS No.	11032-41-0
Molecular Formula	C34H41N5O5 • CH4O3S
Molecular Weight	679.80 g/mol
Synonyms	DHE Mesylate; 9,10-Dihydroergotamine Methanesulfonate; Dihydroergotamine Methanesulfonate; Dihydroergotamine Mesilate; Dihydroergotamine Metilsulfate; (5'α)-9,10-Dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)ergotaman-3',6',18-trione methanesulfonate; Migranal (brand name component); Seglor (brand name component)
EINECS	Contact for details

Quality Control

Our Dihydroergotamine Mesylate is manufactured under strict quality management systems. It is suitable for use in pharmaceutical applications and is tested to meet high-purity standards. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing purity, identity, and impurity profiles. We can support compliance with major pharmacopeial standards (e.g., USP, EP) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure the container is sealed tightly after each use to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	White or almost white, crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (KF)	≤ 5.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%
Microbial Enumeration	Meets requirements for pharmaceutical substances

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.