Description

Pizotifen is a potent serotonin antagonist and antihistamine agent, primarily recognized for its therapeutic applications. This compound is valued for its specific pharmacological activity in modulating neurotransmitter pathways. It is a critical active pharmaceutical ingredient (API) for the development and production of prophylactic migraine medications, serving the needs of the global pharmaceutical and life sciences industries.

Application

• Pharmaceutical API: Primary use as the active ingredient in migraine prophylaxis formulations.
• Neurological Research: Used as a reference standard and tool compound in studies of serotonin (5-HT) receptors and histamine H1 receptors.
• Drug Development: Serves as a key intermediate or final API in the synthesis of finished dosage forms such as tablets.
• Clinical Manufacturing: Employed in the production of batches for clinical trials and commercial pharmaceutical products.
• Analytical Standard: Utilized as a high-purity standard for quality control testing, method development, and validation in analytical laboratories.

Basic Information

Item	Detail
Product Name	Pizotifen
CAS No.	15574-96-6
Molecular Formula	C19H21NS
Molecular Weight	295.44 g/mol
Synonyms	Pizotyline; BC-105; 4-(9,10-Dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-4-ylidene)-1-methylpiperidine; 1-Methyl-4-(4,9-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-4-ylidene)piperidine; Pizotifan; Sandomigran; Mosegor; Litec
EINECS	Contact for details

Quality Control

Our Pizotifen is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity pharmaceutical standards, with specifications aligned with major pharmacopoeial requirements. A Certificate of Analysis (COA) documenting identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.