Description

Rizatriptan is a potent and selective serotonin (5-HT1B/1D) receptor agonist, widely recognized for its therapeutic efficacy. This active pharmaceutical ingredient (API) is critical for the formulation of fast-acting migraine treatments, offering significant relief from acute symptoms. It is essential for pharmaceutical manufacturers and research institutions engaged in developing and producing advanced neurological and analgesic medications.

Application

• Primary Pharmaceutical Ingredient: Core active component in the manufacture of oral tablets and orally disintegrating tablets (ODTs) for the acute treatment of migraine with or without aura.
• Generic Drug Formulation: Serves as the key API for generic pharmaceutical companies producing bioequivalent versions of branded migraine medications.
• Research & Development: Used in preclinical and clinical research to study serotonin receptor pharmacology and develop new therapeutic agents for headache disorders.
• Dosage Form Development: Employed in the development of novel drug delivery systems aimed at improving the speed of onset and patient compliance.
• Reference Standard: High-purity grades are utilized as analytical reference standards in quality control laboratories for HPLC, LC-MS, and other pharmacopeial testing methods.

Basic Information

Product Name	Rizatriptan
CAS No.	144034-80-0
Molecular Formula	C15H19N5
Molecular Weight	269.35 g/mol
Synonyms	Rizatriptan Benzoate; MK-0462; N,N-Dimethyl-2-[5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethylamine; 3-[2-(Dimethylamino)ethyl]-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole; Maxalt® (Brand Name)
EINECS	Contact for details

Quality Control

Our Rizatriptan is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including identification, assay, and impurity profiling (including specified and unspecified impurities, residual solvents) to ensure compliance with USP/EP/ICH guidelines. A detailed Certificate of Analysis (COA) documenting purity, physical characteristics, and chromatographic data is provided with every shipment to guarantee traceability and regulatory readiness.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, 15-25°C (59-77°F). The product is light-sensitive and should be handled under appropriate conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	NMT 1.0%
Residue on Ignition	NMT 0.1%
Related Substances (HPLC)	Total impurities: NMT 1.0% Any individual impurity: NMT 0.5%
Heavy Metals	NMT 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.