Description

Mk 0974, Telcagepant is a high-purity, small molecule pharmaceutical intermediate and reference standard. This compound is a potent and selective calcitonin gene-related peptide (CGRP) receptor antagonist, representing a significant class of therapeutic agents. It is primarily utilized by pharmaceutical R&D departments, contract research organizations (CROs), and manufacturers developing next-generation migraine therapeutics. The product is supplied with full analytical documentation to support critical research and development workflows.

Application

• Pharmaceutical Reference Standard: For use in analytical method development, validation, and quality control (QC) testing of active pharmaceutical ingredients (APIs).
• Migraine Drug Research: As a key pharmacological tool and precursor in the research and development of CGRP antagonist-based therapies for acute and chronic migraine.
• Biochemical Assay Development: Employed in in vitro screening assays to study CGRP receptor binding affinity and functional activity.
• Process Chemistry & Scale-Up: Serves as an intermediate or starting material for the synthesis of novel analogs and derivatives in medicinal chemistry programs.
• Academic Research: Used in university and institutional labs for neuropharmacology studies related to CGRP signaling pathways.
• Regulatory Submissions: Provides certified material for inclusion in regulatory filings (e.g., IND, NDA) to support drug candidate characterization.

Basic Information

Product Name	Mk 0974, Telcagepant
CAS No.	781649-09-0
Molecular Formula	C29H33FN6O3
Molecular Weight	532.61 g/mol
Synonyms	Telcagepant; MK-0974; MK0974; N-[(3R,6S)-6-(2,3-Difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)-5,6-dihydro-1H,3H,4H-pyrrolo[1,2-a]pyrazin-3-yl]-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide; (3R,6S)-N-[6-(2,3-Difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)-1,3,4,5,6,7-hexahydropyrrolo[1,2-a]pyrazin-3-yl]-4-(2-oxo-1(2H)-imidazo[4,5-b]pyridinyl)piperidine-1-carboxamide
EINECS	Contact for details

Quality Control

Our Mk 0974, Telcagepant is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and assay, residual solvent analysis (GC), and structural confirmation (NMR, MS, IR). We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your internal quality standards and regulatory requirements for research use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum matches reference
Purity (HPLC)	≥ 98.0%
Assay (HPLC)	97.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.