Description

Raseglurant CAS NO 757950-09-7 is a potent and selective metabotropic glutamate receptor subtype 5 (mGluR5) negative allosteric modulator. This compound is a critical research tool for investigating the role of glutamate signaling in the central nervous system and has been evaluated in clinical studies for various therapeutic applications. It is primarily utilized by pharmaceutical researchers, contract research organizations (CROs), and academic institutions engaged in neuroscience, pharmacology, and drug discovery programs.

Application

• Neuroscience Research: Used as a reference standard and pharmacological tool to study mGluR5 receptor function and glutamatergic pathways.
• Drug Discovery & Development: Serves as a key intermediate or active pharmaceutical ingredient (API) in preclinical and clinical research for central nervous system (CNS) disorders.
• Pharmacological Studies: Employed in vitro and in vivo to investigate potential therapeutic applications for conditions such as migraine, anxiety, and gastroesophageal reflux disease (GERD).
• Biochemical Assay Development: Utilized in high-throughput screening (HTS) and binding assays to identify and characterize new mGluR5 modulators.
• Academic Research: Supports fundamental research into synaptic transmission, neuronal plasticity, and the pathophysiology of neurological and psychiatric diseases.

Basic Information

Product Name	Raseglurant
CAS No.	757950-09-7
Molecular Formula	C₂₀H₂₀F₃N₅O₂
Molecular Weight	419.40 g/mol
Synonyms	AFQ-056; ADX-10059; 2-[(3-Fluorophenyl)ethynyl]-4,6-dimethyl-N-[3-(1H-1,2,4-triazol-1-yl)propyl]pyrimidin-5-amine; 4,6-Dimethyl-2-(3-fluorophenylethynyl)-5-[[3-(1H-1,2,4-triazol-1-yl)propyl]amino]pyrimidine; mGluR5 NAM
EINECS	Contact for details

Quality Control

Our Raseglurant is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	<10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.