Description

Cafergot is a well-established pharmaceutical compound, a combination of ergotamine tartrate and caffeine, primarily used in the treatment of acute migraine and cluster headaches. Its value lies in its vasoconstrictive properties, which help to alleviate the severe pain associated with these conditions by narrowing blood vessels around the brain. This product is essential for pharmaceutical manufacturers and compounding pharmacies focused on producing effective migraine relief medications. Cafergot CAS NO 69063-86-1 is supplied with a commitment to the stringent quality and consistency required for active pharmaceutical ingredient (API) production.

Application

• Pharmaceutical API: Primary use as the active ingredient in prescription medications for the acute treatment of migraine and cluster headaches.
• Tablet Formulation: Direct compression or granulation for the production of oral tablets and sublingual formulations.
• Compounding Pharmacy: Used by specialized pharmacies to prepare customized dosage forms for patients with specific needs.
• Clinical Research: Serves as a reference standard or raw material in pharmacological studies and clinical trials related to headache disorders and vascular research.
• Generic Drug Manufacturing: A key component for companies producing generic versions of established migraine therapies.

Basic Information

Product Name	Cafergot
CAS No.	69063-86-1
Molecular Formula	C70H78N10O14 • C8H10N4O2
Molecular Weight	1313.44 g/mol (Ergotamine Tartrate) + 194.19 g/mol (Caffeine)
Synonyms	Ergotamine and Caffeine; Ergotamine Tartrate with Caffeine; Migergot; Ercaf; Wigraine; Ergotamine-Caffeine Combination; (5'α)-12'-Hydroxy-2'-methyl-3',6',18-trione-5'-(phenylmethyl)ergotaman-2-carboxamide tartrate with 1,3,7-Trimethylpurine-2,6-dione
EINECS	Contact for details

Quality Control

Our Cafergot is manufactured and tested to meet the rigorous standards required for pharmaceutical actives. Quality assurance includes comprehensive analytical testing for identity, potency, purity, and the control of specific impurities and residual solvents. Each batch is supported by a detailed Certificate of Analysis (COA), ensuring traceability and compliance with current Good Manufacturing Practices (cGMP) and relevant pharmacopeial guidelines (e.g., USP, EP).

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15°C and 25°C (59°F and 77°F). The product is light-sensitive and should be handled and stored accordingly to maintain stability and potency.

Specification

Item	Specification
Description	White or almost white, crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5%; Total impurities: ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Microbial Enumeration	Complies with Ph. Eur. 2.6.12 / USP <61>

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.