Description

Dihydroergotamine Mesylate is a semi-synthetic ergot alkaloid derivative, a key pharmaceutical active ingredient. It is valued for its potent and selective agonist activity at serotonin (5-HT1) receptors, which is critical for therapeutic efficacy. This compound is primarily required by the pharmaceutical industry for the formulation of migraine and cluster headache treatments, as well as for advanced research in neuropharmacology.

Application

• Pharmaceutical Active Ingredient (API): Primary use in the formulation of injectable and nasal spray medications for the acute treatment of migraine and cluster headaches.
• Neurological Research: Used as a reference standard and tool compound in studies investigating serotonin receptor mechanisms, vascular biology, and neuropharmacology.
• Analytical Standard: Serves as a high-purity certified reference material (CRM) for quality control and method validation in analytical laboratories.
• Drug Development: Employed in preclinical and formulation development for new therapeutic agents targeting vascular and neurological disorders.

Basic Information

Product Name	Dihydroergotamine Mesylate
CAS No.	6190-39-2
Molecular Formula	C33H37N5O5 · CH4O3S
Molecular Weight	679.78 g/mol
Synonyms	Dihydroergotamine Methanesulfonate; DHE Mesylate; 9,10-Dihydroergotamine Mesylate; Dihydroergotaminium Mesylate; (5'α)-9,10-Dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)ergotaman-3',6',18-trione Monomethanesulfonate; Dihydroergotamine Metilsulfate; Dihydroergotamine Methylsulfonate; Dihydroergotamine Sulfonate; Dihydroergotamine Mesilate
EINECS	228-247-7

Quality Control

Our Dihydroergotamine Mesylate is manufactured under strict quality management systems. It is tested to meet high-purity standards suitable for pharmaceutical applications, with specifications aligning with pharmacopeial expectations. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing purity, identity, and impurity profiles to ensure traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White or almost white, crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.