Description

Olcegepant (Hydrochloride) is a potent and selective non-peptide antagonist of the calcitonin gene-related peptide (CGRP) receptor. This compound is of significant interest in pharmaceutical research and development, particularly for its potential role in the treatment of migraine and other neurovascular disorders. It is a critical reference standard and active pharmaceutical ingredient (API) for researchers and manufacturers in the global pharmaceutical and biotechnology sectors.

Application

• Pharmaceutical Reference Standard: Used for analytical method development, validation, and quality control in API and finished product testing.
• Migraine Research: Serves as a key pharmacological tool in preclinical studies to investigate CGRP receptor pathways and novel therapeutic mechanisms.
• Drug Development: Employed as a lead compound or intermediate in the synthesis and development of new CGRP receptor antagonists.
• Biochemical Assays: Utilized in high-throughput screening (HTS) and in vitro binding studies to assess receptor affinity and selectivity.
• Academic Research: Supports fundamental neuroscience and cardiovascular research exploring the role of CGRP in various physiological and pathological processes.

Basic Information

Product Name	Olcegepant (Hydrochloride)
CAS No.	586368-06-1
Molecular Formula	C34H37ClN6O4 • HCl
Molecular Weight	649.62 g/mol (as hydrochloride salt)
Synonyms	BIBN-4096BS; BIBN 4096 BS; Olcegepant HCl; 1-Piperidinecarboxamide, N-[2-[[5-amino-1-[[4-(4-pyridinyl)-1-piperazinyl]carbonyl]pentyl]amino]-1-[(3,5-dibromo-4-hydroxyphenyl)methyl]-2-oxoethyl]-4-(1,4-dihydro-2-oxo-3(2H)-quinazolinyl)-, hydrochloride (1:1); N-[2-[[5-Amino-1-[[4-(4-pyridinyl)-1-piperazinyl]carbonyl]pentyl]amino]-1-[(3,5-dibromo-4-hydroxyphenyl)methyl]-2-oxoethyl]-4-(1,4-dihydro-2-oxo-3(2H)-quinazolinyl)-1-piperidinecarboxamide monohydrochloride
EINECS	Contact for details

Quality Control

Our Olcegepant (Hydrochloride) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods (IR, NMR, MS), and residual solvent analysis to ensure compliance with ICH guidelines. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming the product meets the agreed specifications for pharmaceutical research use.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. Due to its hygroscopic nature, the container should be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.