Description

(5'α,10α)-6-Demethyl-9,10-Dihydro-12'-Hydroxy-2'-Methyl-5'-(Phenylmethyl)Ergotaman-3',6',18-Trione is a complex ergot alkaloid derivative with significant pharmacological research interest. This compound serves as a critical advanced intermediate in the synthesis of novel therapeutic agents targeting neurological and cardiovascular systems. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of specialized APIs. The compound's unique structure makes it a valuable scaffold for medicinal chemistry and pharmacological studies.

Application

• Pharmaceutical Intermediate: Key building block in the research and synthesis of novel ergot-based active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a precursor or reference standard in the development of new compounds with potential dopaminergic or serotonergic activity.
• Biochemical Tool Compound: Employed in in-vitro studies to investigate receptor binding affinity and signal transduction pathways.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.
• Academic Research: Utilized in university and institutional research programs focusing on alkaloid chemistry and drug discovery.

Basic Information

Product Name	(5'α,10α)-6-Demethyl-9,10-Dihydro-12'-Hydroxy-2'-Methyl-5'-(Phenylmethyl)Ergotaman-3',6',18-Trione
CAS No.	57123-71-4
Molecular Formula	C32H35N3O5
Molecular Weight	541.64 g/mol
Synonyms	6-Demethyl-9,10-dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)ergotaman-3',6',18-trione; 6-Nor-6-demethyl-9,10-dihydrolysergol derivative; 5'α,10α-Ergotaman derivative; 12'-Hydroxy-2'-methyl-5'-benzylergotaman-trione; (5'α,10α)-Dihydro-12'-hydroxy-2'-methyl-5'-benzylergotaman-3',6',18-trione; 6-Nordihydroergotamine analog; 57123-71-4; 5'α,10α-Dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)ergotaman-3',6',18-trione
EINECS	Contact for details

Quality Control

Our (5'α,10α)-6-Demethyl-9,10-Dihydro-12'-Hydroxy-2'-Methyl-5'-(Phenylmethyl)Ergotaman-3',6',18-Trione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC purity assay, identity confirmation (IR, MS), and residual solvent analysis, to ensure it meets the stringent requirements for research and development use. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.