Description

6-Demethyl-9,10-Dihydro-12'-Hydroxy-2'-Methyl-6-(1-Methylethyl)-5'-(Phenylmethyl)Ergotaman-3',6',18-Trione is a complex ergot alkaloid derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate or reference standard for the synthesis and study of novel therapeutic agents targeting neurological and cardiovascular systems. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of specialized APIs and high-potency drugs. The material's specific stereochemistry and functional groups make it a valuable building block for creating molecules with precise biological activity.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the multi-step synthesis of novel ergot-based active pharmaceutical ingredients (APIs).
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control of related pharmaceutical compounds via HPLC, LC-MS, or NMR.
• Biochemical Research: Employed in pharmacological studies to investigate receptor binding affinity, particularly with serotonin (5-HT) and dopamine receptors, aiding in drug discovery.
• Process Chemistry Development: Utilized for scaling up and optimizing synthetic routes for complex alkaloid derivatives in pilot plants.
• Academic Research: A valuable compound for universities and research institutes studying the chemistry, biosynthesis, and medicinal properties of ergot alkaloids.

Basic Information

Product Name	6-Demethyl-9,10-Dihydro-12'-Hydroxy-2'-Methyl-6-(1-Methylethyl)-5'-(Phenylmethyl)Ergotaman-3',6',18-Trione
CAS No.	57123-67-8
Molecular Formula	C34H38N4O5
Molecular Weight	582.69 g/mol
Synonyms	9,10-Dihydro-12'-hydroxy-2'-methyl-6-(1-methylethyl)ergotaman-3',6',18-trione, 6-demethyl-5'-(phenylmethyl)-; 6-Demethyl-9,10-dihydro-12'-hydroxy-2'-methyl-6-isopropyl-5'-benzylergotaman-3',6',18-trione; 6-Desmethyl-9,10-dihydro-12'-hydroxy-2'-methyl-6-isopropyl-5'-benzylergotaman-3',6',18-trione; A derivative of Dihydroergocristine; Ergoline alkaloid derivative; 6-Isopropyl-5'-benzyl-6-demethyl-9,10-dihydro-12'-hydroxy-2'-methylergotaman-3',6',18-trione
EINECS	Contact for details

Quality Control

Our 6-Demethyl-9,10-Dihydro-12'-Hydroxy-2'-Methyl-6-(1-Methylethyl)-5'-(Phenylmethyl)Ergotaman-3',6',18-Trione is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or development specifications. Our commitment to consistency and purity supports critical pharmaceutical and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.