Description

Isometheptene Maleate is a pharmaceutical-grade active pharmaceutical ingredient (API) with the CAS registry number 51277-00-0. This compound is valued for its vasoconstrictive properties, making it a critical component in the formulation of specific therapeutic agents. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of migraine and tension headache medications. Our supply ensures high purity and consistent quality to meet stringent pharmacopeial standards.

Application

• Pharmaceutical API: Primary use as the active ingredient in prescription medications for the treatment of migraine and vascular headaches.
• Analgesic Formulations: A key component in combination drugs that also contain analgesics like acetaminophen and caffeine for enhanced therapeutic effect.
• Vasoconstrictor Research: Used in preclinical and clinical research studies investigating compounds that affect cranial blood vessels.
• Reference Standard: Serves as a high-purity chemical reference standard for quality control and analytical testing in pharmaceutical laboratories.
• Drug Development: Employed in the R&D phase for developing new dosage forms, such as tablets, capsules, or controlled-release formulations.

Basic Information

Product Name	Isometheptene Maleate
CAS No.	51277-00-0
Molecular Formula	C13H21NO2 • C4H4O4
Molecular Weight	295.33 g/mol (free base: 155.24 g/mol)
Synonyms	Isometheptene Hydrogen Maleate; 6-Methyl-2-methylaminohept-2-ene maleate; 1,5-Dimethyl-4-hexenylamine maleate; Octin; Midrin (component); N-Methyl-6-methyl-2-heptenylamine maleate; 2-Methylamino-6-methylhept-2-ene maleate
EINECS	Contact for details

Quality Control

Our Isometheptene Maleate is manufactured under strict quality management systems. Each batch is tested to ensure compliance with relevant pharmacopeial standards, including identification, purity, and impurity profiles. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing results from tests such as HPLC assay, residual solvents, heavy metals, and related substances. We support audits and can provide documentation for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.