Description

Dihydroergotamine Tartrate Crystalline CAS NO 5989-77-5 is a high-purity, crystalline salt form of dihydroergotamine, a semi-synthetic ergot alkaloid derivative. It is a critical active pharmaceutical ingredient (API) valued for its potent vasoconstrictive and serotonin receptor agonist properties. This compound is essential for manufacturers in the pharmaceutical industry developing specific migraine and headache treatments, as well as for research institutions conducting neurological and cardiovascular studies.

Application

• Pharmaceutical API: Primary active ingredient in injectable and nasal spray formulations for the acute treatment of migraine and cluster headaches.
• Neurological Research: Used as a reference standard and tool compound in studies targeting 5-HT1B/1D serotonin receptors.
• Vascular Research: Employed in preclinical research to study vasoconstriction and vascular smooth muscle activity.
• Reference Standard: Serves as a certified reference material (CRM) for quality control and analytical method development in pharmaceutical labs.
• Drug Development: Key intermediate or final API in the R&D pipeline for new neurological and cardiovascular therapeutics.
• Generic Drug Manufacturing: Sourced for the production of generic versions of established dihydroergotamine-based medications.

Basic Information

Product Name	Dihydroergotamine Tartrate Crystalline
CAS No.	5989-77-5
Molecular Formula	C37H43N5O11 • C4H6O6
Molecular Weight	855.9 g/mol
Synonyms	Dihydroergotamine Mesylate (salt form variant); DHE Tartrate; 9,10-Dihydroergotamine Tartrate; Dihydroergotamine Bitartrate; Dihydroergotamine Hydrogen Tartrate; (5'α)-9,10-Didehydro-12'-hydroxy-2'-methyl-3,6,18-trione-5'-(phenylmethyl)ergotaman Tartrate; Migranal® (brand name formulation) API; Dihydroergotamine (base)
EINECS	227-816-3

Quality Control

Our Dihydroergotamine Tartrate Crystalline is manufactured and tested to meet stringent pharmaceutical-grade standards. Quality assurance protocols are designed to comply with current Good Manufacturing Practices (cGMP) and relevant pharmacopoeial monographs (e.g., USP, Ph. Eur.). Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles to ensure supply reliability and regulatory compliance for our global partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a low-humidity environment to prevent degradation. For long-term stability, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White or almost white, crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (Karl Fischer)	≤ 5.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%
Heavy Metals	≤ 20 ppm
Microbial Enumeration	Meets Ph. Eur. 2.6.12 / USP <61> requirements

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.