Description

2'-Epidihydroergotamine is a key ergot alkaloid derivative and a stereoisomer of dihydroergotamine. This compound is of significant interest in pharmaceutical research and development, particularly as a reference standard and a potential synthetic intermediate. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development and quality control of cardiovascular and neurological therapeutics. The material is supplied with a high level of purity to meet the stringent demands of analytical and process chemistry.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified reference material (CRM) for analytical method development, validation, and quality control testing of active pharmaceutical ingredients (APIs).
• Biochemical Research: Serves as a critical tool in pharmacological studies to investigate receptor binding activity, particularly at serotonin (5-HT) and adrenergic receptors.
• Process Chemistry Intermediate: Acts as a chiral building block or precursor in the synthetic pathways for more complex ergot-based pharmaceutical compounds.
• Metabolite Studies: Employed in the identification and quantification of metabolites in pharmacokinetic and bioanalytical research related to ergotamine therapeutics.

Basic Information

Product Name	2'-Epidihydroergotamine
CAS No.	5550-75-4
Molecular Formula	C33H37N5O5
Molecular Weight	583.68 g/mol
Synonyms	2'-Epidihydroergotamine; 9,10-Didehydro-N-[2-hydroxy-1-(hydroxymethyl)propyl]-6-methylergoline-8β-carboxamide; (8β)-9,10-Didehydro-N-[2-hydroxy-1-(hydroxymethyl)propyl]-6-methylergoline-8-carboxamide; Dihydroergotamine Impurity; DHE Epimer; Ergot Alkaloid Derivative
EINECS	Contact for details

Quality Control

Every batch of 2'-Epidihydroergotamine is manufactured and tested under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment. We can support development projects requiring compliance with ICH guidelines and other pharmacopeial standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.