Description

Lasmiditan Succinate (USAN) is a highly selective serotonin (5-HT) 1F receptor agonist, representing a novel therapeutic class for the acute treatment of migraine. Its distinct mechanism of action, devoid of vasoconstrictive effects, makes it a critical active pharmaceutical ingredient (API) for pharmaceutical development targeting patients with cardiovascular risk factors. This compound is essential for manufacturers in the global pharmaceutical industry engaged in the formulation of innovative neurological therapeutics, particularly for migraine-specific medications.

Application

• Primary Active Pharmaceutical Ingredient (API) in the formulation of oral tablets for the acute treatment of migraine.
• Key intermediate in advanced pharmaceutical research and development of neurological disorder treatments.
• Reference standard for analytical method development and validation in quality control laboratories.
• Critical material for clinical trial material (CTM) manufacturing in Phase II and III studies.
• Building block for pharmacological studies investigating 5-HT1F receptor pathways.
• Raw material for the synthesis of related novel triptan-class derivatives in medicinal chemistry.

Basic Information

Product Name	Lasmiditan Succinate (USAN)
CAS No.	439239-92-6
Molecular Formula	C19H20F3N3O2 • C4H6O4
Molecular Weight	481.44 g/mol
Synonyms	Lasmiditan Succinate; Lasmiditan Hemisuccinate; 2,4,6-Trifluoro-N-[6-(1-methylpiperidin-4-yl)pyridin-2-yl]benzamide hemisuccinate; COL-144 Succinate; LY573144 Succinate; REYVOW™ (Brand Name) API; 5-HT1F Receptor Agonist Succinate Salt
EINECS	Contact for details

Quality Control

Our Lasmiditan Succinate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for pharmaceutical use, including identity, purity, and impurity profiles. Certificates of Analysis (COA) documenting compliance with relevant pharmacopeial standards (such as USP monographs where applicable) are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under conditions that minimize exposure to atmospheric humidity to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Heavy Metals	≤ 20 ppm
Microbial Enumeration	Meets Ph. Eur. 2.6.12 / USP <61>

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.