Description

9,10Alpha-Dihydro-12'-Hydroxy-5'α-Isobutyl-2'-Isopropylergotaman-3',6',18-Trione Methanesulphonate is a high-purity, semi-synthetic ergot alkaloid derivative, valued for its specific pharmacological activity and role as a critical intermediate in advanced pharmaceutical synthesis. This compound is essential for research and development in the life sciences sector, particularly for creating novel therapeutic agents targeting neurological and vascular systems. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic research institutions engaged in drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex, high-value active pharmaceutical ingredients (APIs) with targeted biological activity.
• Neurological Research: Used as a reference standard and precursor in preclinical studies investigating compounds that interact with neurotransmitter systems.
• Vasoconstrictor Studies: Serves as a model compound or starting material for developing agents that affect vascular smooth muscle tone.
• Process Development: Employed in the optimization and scale-up of synthetic routes for ergot-derived pharmaceuticals under Good Manufacturing Practice (GMP) conditions.
• Analytical Standard: Utilized as a certified reference material (CRM) for method development, validation, and quality control testing in analytical laboratories.
• Academic Research: Supports chemical and pharmacological research in university and institutional labs focusing on alkaloid chemistry and medicinal chemistry.

Basic Information

Item	Details
Product Name	9,10Alpha-Dihydro-12'-Hydroxy-5'α-Isobutyl-2'-Isopropylergotaman-3',6',18-Trione Methanesulphonate
CAS No.	29261-93-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	12'-Hydroxy-5'α-isobutyl-2'-isopropylergotaman-3',6',18-trione methanesulfonate; 9,10-Dihydro-12'-hydroxy-5'α-isobutyl-2'-isopropylergotaman-3',6',18-trione methanesulfonate; Methanesulfonic acid, compd. with 9,10-dihydro-12'-hydroxy-5'α-isobutyl-2'-isopropylergotaman-3',6',18-trione; Dihydroergotamine impurity/intermediate; Ergotaman derivative methanesulfonate salt.
EINECS	Contact for details

Quality Control

Our 9,10Alpha-Dihydro-12'-Hydroxy-5'α-Isobutyl-2'-Isopropylergotaman-3',6',18-Trione Methanesulphonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatographic purity assays and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical methods is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.