Description

Dihydroergocornine is a semi-synthetic ergot alkaloid derivative, representing a key intermediate and reference standard in advanced pharmaceutical research and development. Its primary commercial value lies in its role as a precursor for the synthesis of more complex therapeutic agents and its use in analytical and pharmacological studies. This compound is essential for research institutions and pharmaceutical manufacturers focused on neurological and cardiovascular drug discovery, as well as quality control laboratories requiring high-purity reference materials.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of complex ergot-derived active pharmaceutical ingredients (APIs).
• Analytical Reference Standard: Used as a certified reference material (CRM) for the identification, assay, and impurity profiling of related compounds via HPLC, LC-MS, and other chromatographic methods.
• Pharmacological Research: Employed in preclinical studies to investigate the biological activity and receptor binding profiles of ergot alkaloid derivatives.
• Biochemical Tool Compound: Utilized in in vitro assays to study mechanisms related to neurotransmitter modulation and vascular tone.
• Quality Control & Method Development: Essential for developing and validating analytical methods in pharmaceutical quality assurance/quality control (QA/QC) laboratories.

Basic Information

Product Name	Dihydroergocornine
CAS No.	25447-65-8
Molecular Formula	C31H41N5O5
Molecular Weight	563.69 g/mol
Synonyms	Dihydroergocornine; 9,10-Dihydroergocornine; Dihydroergocornin; (5'α)-9,10-Dihydro-12'-hydroxy-2',5'-dimethylergotaman-3',6',18-trione; 9,10-Dihydro-12'-hydroxy-2',5'-dimethylergotaman-3',6',18-trione; Dihydroergocornine base; DHEC
EINECS	Contact for details

Quality Control

Our Dihydroergocornine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) that include results from HPLC purity assays, related substance profiling, and other relevant pharmacopeial tests. Specifications are aligned with the requirements for high-purity pharmaceutical intermediates and reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Due to its sensitivity to light and oxidation, prolonged exposure to air and light should be avoided.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.