Description

Metergotamine is a semi-synthetic ergot alkaloid derivative known for its potent and selective pharmacological profile. This compound is of significant interest in advanced pharmaceutical research and development, particularly for its potential as a reference standard and active pharmaceutical ingredient (API) intermediate. It serves specialized needs within the pharmaceutical and biochemical research sectors, where precise chemical structure and high purity are paramount for developing targeted therapeutic agents.

Application

• Pharmaceutical Reference Standard: Used as a high-purity calibrant in analytical methods (HPLC, LC-MS) for quality control and regulatory compliance.
• Active Pharmaceutical Ingredient (API) Intermediate: A key synthetic precursor in the production of specialized ergot-based medications.
• Biochemical Research: Employed in in vitro and in vivo studies to investigate serotonin receptor (5-HT) interactions and related neurological pathways.
• Pharmacological Development: Serves as a lead compound for developing new agents targeting migraines, vascular disorders, and neuroendocrine regulation.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring ergot alkaloid expertise.

Basic Information

Item	Detail
Product Name	Metergotamine
CAS No.	22336-84-1
Molecular Formula	C₂₀H₂₅N₃O₂
Molecular Weight	339.44 g/mol
Synonyms	Metergoline; Methergoline; 1-Methyl-8β-carbobenzyloxyaminomethyl-10α-ergoline; 1-Methyl-8β-[(benzyloxycarbonyl)aminomethyl]-10α-ergoline; Liserdol; Contralac; FI-6337; CB-154 (Note: CB-154 is more commonly Bromocriptine, but is sometimes incorrectly associated; included for search relevance).
EINECS	Contact for details

Quality Control

Our Metergotamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and MS. We provide full traceability and Certificates of Analysis (COA) that detail all specifications, ensuring the material meets the stringent requirements for research and pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.