Description

5-[3-(Dimethylamino)-2-Methylpropyl]-10,11-Dihydro-5H-Dibenzo[A,D]Cyclohepten-5-Ol is a key pharmaceutical intermediate and organic building block with a complex tricyclic structure. This compound matters for its role in the synthesis of advanced active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) agents and other therapeutic molecules. It is primarily needed by research institutions, pharmaceutical development laboratories, and fine chemical manufacturers engaged in custom synthesis and process chemistry.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of tricyclic antidepressant analogs and other neuroactive compounds.
• Organic Synthesis Building Block: Utilized in research and development for constructing complex dibenzocycloheptene-based molecular architectures.
• Medicinal Chemistry Research: Serves as a scaffold for structure-activity relationship (SAR) studies in drug discovery programs targeting neurological pathways.
• Reference Standard: Used as an analytical standard in quality control laboratories for method development and impurity profiling.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for pilot plant and commercial manufacturing.

Basic Information

Product Name	5-[3-(Dimethylamino)-2-Methylpropyl]-10,11-Dihydro-5H-Dibenzo[A,D]Cyclohepten-5-Ol
CAS No.	2625-17-4
Molecular Formula	C21H27NO
Molecular Weight	309.45 g/mol
Synonyms	10,11-Dihydro-5-[3-(dimethylamino)-2-methylpropyl]-5H-dibenzo[a,d]cyclohepten-5-ol; 5-(3-Dimethylamino-2-methylpropyl)-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ol; 5H-Dibenzo[a,d]cyclohepten-5-ol, 10,11-dihydro-5-[3-(dimethylamino)-2-methylpropyl]-; Desmethylprotriptyline; Norprotriptyline; NSC 108034; Protriptyline Impurity; Protriptyline Related Compound A
EINECS	Contact for details

Quality Control

Our 5-[3-(Dimethylamino)-2-Methylpropyl]-10,11-Dihydro-5H-Dibenzo[A,D]Cyclohepten-5-Ol is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided and can be tailored to meet specific customer requirements for research or cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed to protect from moisture and contamination.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.