Description

Vazegepant Hcl CAS NO 1414976-20-7 is a high-purity, small molecule pharmaceutical active ingredient belonging to the gepant class of calcitonin gene-related peptide (CGRP) receptor antagonists. This compound is critical for the research and development of novel therapeutic agents targeting migraine and other neurological disorders. It is primarily required by pharmaceutical R&D laboratories, contract research and manufacturing organizations (CROs/CMOs), and academic institutions engaged in neuroscience and drug discovery.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control testing of drug products.
• Clinical Research Material: Serves as a key intermediate or active pharmaceutical ingredient (API) in pre-clinical and clinical trial formulations.
• Mechanistic & Pharmacological Studies: Employed in in vitro and in vivo studies to investigate CGRP pathway biology and the efficacy of receptor antagonism.
• Process Chemistry & Development: Used as a benchmark in the development and optimization of synthetic routes for scale-up manufacturing.
• Impurity Profiling: Acts as a primary standard for identifying and quantifying related substances and degradation products in compliance with ICH guidelines.

Basic Information

Product Name	Vazegepant Hcl
CAS No.	1414976-20-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Vazegepant Hydrochloride; (1R,5S)-N-[3-(5-Amino-1,2,4-oxadiazol-3-yl)phenyl]-3-[(2-fluoro-4-[(5-fluoro-2-pyrimidinyl)oxy]phenyl)methyl]-3,8-diazabicyclo[3.2.1]octane-8-carboxamide hydrochloride; Vazegepant HCl; Vazegepant (Hydrochloride); BHV-3500 (Hydrochloride)
EINECS	Contact for details

Quality Control

Our Vazegepant Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing results for assay, related substances, residual solvents, and other critical parameters is provided with every shipment to ensure full traceability and regulatory support.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities: ≤2.0% Any single unknown impurity: ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.