Description

Ubrogepant CAS NO 1374248-77-7 is a potent and selective small-molecule calcitonin gene-related peptide (CGRP) receptor antagonist. This compound is of significant commercial and therapeutic interest as an acute treatment for migraine headaches. It is primarily required by pharmaceutical manufacturers, research institutions, and contract development and manufacturing organizations (CDMOs) involved in neurology and central nervous system (CNS) drug development.

Application

• Active Pharmaceutical Ingredient (API) for the formulation of oral migraine medications.
• Reference Standard for quality control and analytical method development in pharmaceutical laboratories.
• Research Chemical for preclinical and clinical studies investigating CGRP pathway pharmacology.
• Process Development for scale-up synthesis and optimization of manufacturing routes.
• Regulatory Submissions, supporting drug master files (DMFs) and new drug applications (NDAs).

Basic Information

Product Name	Ubrogepant
CAS No.	1374248-77-7
Molecular Formula	C19H21F2N7O
Molecular Weight	401.42 g/mol
Synonyms	MK-1602; Ubrelvy (Trade Name); (3S)-N-[(3S,5S,6R)-6-Methyl-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5-azaspiro[2.4]heptan-5-yl]-3-(2,2-difluorocyclopropyl)carbonyl]-3,4-difluoro-L-phenylalanine; 1-[[(3S)-3-[[(3S,5S,6R)-6-Methyl-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5-azaspiro[2.4]hept-5-yl]carbonylamino]-4,4-difluoro-1-oxopentan-2-yl]amino]-2,2-difluorocyclopropanecarboxylic acid
EINECS	Contact for details

Quality Control

Our Ubrogepant is manufactured under strict quality management systems. It undergoes rigorous analytical testing to ensure compliance with ICH guidelines and meets high-purity standards suitable for pharmaceutical development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each batch and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.