Description

Rimegepant Sulfate is a high-purity active pharmaceutical ingredient (API) and a potent, selective calcitonin gene-related peptide (CGRP) receptor antagonist. It is a critical component in the development and manufacture of novel therapeutic agents for the acute treatment of migraine. This compound is essential for pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and finished dosage formulators targeting neurological disorders.

Application

• Pharmaceutical API: Primary active ingredient in the formulation of migraine treatment medications.
• Reference Standard: Used as a certified reference material (CRM) in analytical method development and validation for quality control laboratories.
• Research & Development: Key intermediate or target molecule in preclinical and clinical studies for neurological and pain management pathways.
• Drug Substance Manufacturing: Sourced by CMOs for scale-up and commercial production under cGMP guidelines.
• Formulation Development: Utilized in the development of various dosage forms, including orally disintegrating tablets (ODTs).

Basic Information

Product Name	Rimegepant Sulfate
CAS No.	1374024-48-2
Molecular Formula	C28H28F2N6O3 • H2SO4
Molecular Weight	606.64 g/mol (as sulfate salt)
Synonyms	BMS-927711; Rimegepant hydrogen sulfate; (5S,6S,9R)-5-Amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridine-9-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate sulfate; NURTEC ODT (rimegepant) API; BHV-3000 (rimegepant) sulfate.
EINECS	Contact for details

Quality Control

Our Rimegepant Sulfate is manufactured and controlled under a strict quality management system. Each batch is tested to ensure it meets stringent specifications for identity, purity, and potency, aligning with ICH guidelines. A comprehensive Certificate of Analysis (COA) detailing results for assay, related substances, residual solvents, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, 15-25°C (59-77°F). The material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 5.0% w/w
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Sulfate Content	Conforms to theoretical stoichiometry

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.