Description

Spiro Almotriptan CAS NO 1309457-18-8 is a high-purity pharmaceutical intermediate and active ingredient. This compound is critical for the research and development of advanced therapeutic agents targeting neurological pathways. It is primarily utilized by pharmaceutical manufacturers and R&D laboratories engaged in the synthesis of novel drug candidates for migraine and related CNS disorders.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs) for migraine therapeutics.
• Neurological Research: Used in preclinical and clinical research for developing new treatments targeting serotonin (5-HT1B/1D) receptors.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development and quality control in pharmaceutical analysis.
• Process Chemistry: Employed in scale-up and optimization studies for robust and cost-effective API manufacturing processes.
• Academic Research: Utilized in university and institutional labs for pharmacological studies and chemical synthesis projects.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	Spiro Almotriptan
CAS No.	1309457-18-8
Molecular Formula	C17H25N3O2S
Molecular Weight	335.47 g/mol
Synonyms	Almotriptan Spiro Intermediate; 1-[[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]methyl]-N-methyl-2-pyrrolidinecarboxamide; Almotriptan Related Compound; Almotriptan Impurity; AXERT Intermediate; Migraine Drug Intermediate; 5-HT1B/1D Receptor Agonist Intermediate
EINECS	Contact for details

Quality Control

Our Spiro Almotriptan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, confirming compliance with client specifications and relevant ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 99.0%
Single Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.