Description

Rimegepant CAS NO 1289023-67-1 is a potent and selective small molecule calcitonin gene-related peptide (CGRP) receptor antagonist. This compound is of significant commercial and therapeutic interest for its targeted mechanism of action. It is primarily required by pharmaceutical manufacturers and research organizations engaged in the development and production of advanced neurological therapeutics.

Application

• Pharmaceutical Active Ingredient (API): Primary use as the active pharmaceutical ingredient in the formulation of migraine prevention and acute treatment medications.
• Neurological Research: A critical reference standard and tool compound for in-vitro and in-vivo studies targeting CGRP pathways in migraine, cluster headaches, and other neurovascular disorders.
• Drug Development: Serves as a key intermediate or final API for companies developing generic or novel dosage forms (e.g., orally disintegrating tablets) of rimegepant.
• Analytical Standard: Used as a high-purity certified reference material (CRM) in quality control laboratories for HPLC, LC-MS, or NMR method development and validation.
• Preclinical Studies: Employed in pharmacokinetic, pharmacodynamic, and toxicology studies to support regulatory filings.

Basic Information

Product Name	Rimegepant
CAS No.	1289023-67-1
Molecular Formula	C28H28F2N6O3
Molecular Weight	534.56 g/mol
Synonyms	BMS-927711; Rimegepant sulfate; BHV-3000; (5S,6S,9R)-5-Amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate; NVP-AAD-6681; Zydis ODT (in formulated product)
EINECS	Contact for details

Quality Control

Our Rimegepant is manufactured under strict quality management systems. Each batch is tested to meet high-purity standards suitable for pharmaceutical research and development. Comprehensive testing includes identity confirmation, assay, and control of specified impurities and residual solvents. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to ensure full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.