Description

Cgrp Antagonist 1 CAS NO 1123757-49-2 is a high-purity, small molecule pharmaceutical intermediate designed for research and development. This compound is a key building block in the synthesis of novel therapeutics targeting the calcitonin gene-related peptide (CGRP) pathway, which is crucial for the treatment of migraine and other neurological disorders. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in drug discovery and process chemistry.

Application

• Pharmaceutical R&D: Serves as a critical intermediate in the synthesis of CGRP receptor antagonists for migraine prophylaxis.
• Process Chemistry: Used in scale-up and optimization studies for the commercial manufacturing of active pharmaceutical ingredients (APIs).
• Reference Standard: Acts as a certified reference material (CRM) for analytical method development and validation in quality control laboratories.
• Preclinical Studies: Employed in the formulation of drug candidates for pharmacokinetic and pharmacodynamic evaluations.
• Chemical Biology: Utilized as a tool compound to study the CGRP pathway and its role in pain signaling and vascular biology.
• Custom Synthesis: A starting point for the development of novel analogs and derivatives with potential therapeutic applications.

Basic Information

Product Name	Cgrp Antagonist 1
CAS No.	1123757-49-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	CGRP Antagonist 1; CGRP Receptor Antagonist 1; (2R)-N-[(3R,6S)-6-Methyl-1-(2,2,2-trifluoroethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl]-2-methyl-2-{[4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidin-1-yl]methyl}propanamide; BIBN4096BS; Olcegepant; MK-0974 (related class); Telcagepant (related class)
EINECS	Contact for details

Quality Control

Our Cgrp Antagonist 1 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep the container tightly sealed in a desiccator for long-term storage.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.