Description

Rizatriptan N,N,n-Trimethylethanammonium Chloride is a high-purity pharmaceutical intermediate and reference standard. This compound is critical for ensuring the quality, safety, and efficacy of active pharmaceutical ingredients (APIs) in the final drug product. It is primarily required by pharmaceutical manufacturers and analytical laboratories for the synthesis and quality control of Rizatriptan-based migraine treatments.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of Rizatriptan Benzoate, the active ingredient in migraine relief medications.
• Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control testing in pharmaceutical labs.
• Impurity Standard: Employed in the identification and quantification of related substances during stability studies and release testing of Rizatriptan API.
• Research & Development: Serves as a precursor in the discovery and development of new triptan-based therapeutic agents.
• Regulatory Compliance: Essential for generating data to meet stringent regulatory filing requirements (e.g., FDA, EMA) for new drug applications (NDAs) and abbreviated new drug applications (ANDAs).

Basic Information

Product Name	Rizatriptan N,N,n-Trimethylethanammonium Chloride
CAS No.	1030849-63-8
Molecular Formula	C15H23N3O2 • Cl
Molecular Weight	312.82 g/mol
Synonyms	N,N,N-Trimethyl-2-[5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethanaminium Chloride; Rizatriptan Quaternary Ammonium Salt; Rizatriptan Impurity; Rizatriptan Related Compound; 2-[5-(1H-1,2,4-Triazol-1-ylmethyl)-1H-indol-3-yl]-N,N,N-trimethylethanaminium Chloride; Rizatriptan N-Methyl Quaternary Salt; Rizatriptan Chloride Salt Intermediate
EINECS	Contact for details

Quality Control

Our Rizatriptan N,N,n-Trimethylethanammonium Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and conformity to stringent pharmaceutical-grade specifications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every lot to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to protect from moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.