Description

Tonabersat is a selective and potent connexin hemichannel blocker with significant research and therapeutic potential. This compound is primarily valued for its neuroprotective properties and its role in modulating inflammatory signaling pathways. It is a critical material for pharmaceutical R&D, particularly for researchers and manufacturers developing treatments for neurological disorders, migraine, and other conditions involving gap junction communication.

Application

• Pharmaceutical Research & Development: As a key active pharmaceutical ingredient (API) intermediate or reference standard in preclinical and clinical studies.
• Neurological Disorder Therapeutics: Investigation and development of treatments for conditions like migraine, epilepsy, and neuropathic pain.
• Neuroprotection Studies: Research into mechanisms for protecting neural tissues from injury or degenerative processes.
• Inflammation Modulation: Used in studies targeting inflammatory pathways in the central nervous system.
• Gap Junction & Connexin Research: A vital tool for studying the function and inhibition of connexin hemichannels in cellular communication.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	Tonabersat
CAS No.	175013-84-0
Molecular Formula	C17H14Cl2N2O3
Molecular Weight	365.21 g/mol
Synonyms	SB-220453; (1S,2S)-1-(4-Aminophenyl)-2-(3,4-dichlorophenyl)-N,N-diethylcyclopropanecarboxamide; Xiflam; Tonabersatum; BSP-B 00297746; CCRIS 9385; 1-(4-Aminophenyl)-N,N-diethyl-2-(3,4-dichlorophenyl)cyclopropanecarboxamide
EINECS	Contact for details

Quality Control

Our Tonabersat is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data to support pharmaceutical and research applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.