Description

Donitriptan CAS NO 170912-52-4 is a high-purity pharmaceutical intermediate and research chemical belonging to the triptan class of compounds. It is a critical building block in the synthesis of advanced therapeutic agents targeting neurological conditions. This compound is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of novel migraine treatments and central nervous system (CNS) active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel triptan-based migraine therapeutics and other CNS-active pharmaceutical ingredients.
• Research & Development: Used as a reference standard and active compound in pharmacological studies for serotonin (5-HT1B/1D) receptor agonist research.
• Fine Chemical Synthesis: Serves as a crucial building block for medicinal chemists in creating new chemical entities (NCEs) and optimizing drug candidate structures.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of clinical trial materials and commercial APIs.
• Academic Research: Employed in university and institutional laboratories for neuroscience and neuropharmacology research projects.

Basic Information

Product Name	Donitriptan
CAS No.	170912-52-4
Molecular Formula	C18H24N2O2S
Molecular Weight	332.46 g/mol
Synonyms	Donitriptan; 3-[2-(Dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulfonamide; 5-[(Methylsulfonyl)amino]methyl]-3-[2-(dimethylamino)ethyl]-1H-indole; A-77636; A 77636; A77636; (3-(2-(Dimethylamino)ethyl)-1H-indol-5-yl)-N-methylmethanesulfonamide
EINECS	Contact for details

Quality Control

Our Donitriptan is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. The product undergoes comprehensive analytical testing, including HPLC for assay and impurity profiling, residual solvent analysis, and identity confirmation (IR, NMR). A Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment to guarantee compliance with your research or manufacturing requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.