Description

Donitriptan is a potent and selective serotonin (5-HT1B/1D) receptor agonist, representing a key intermediate in advanced pharmaceutical synthesis. This compound is of critical importance for the research and development of novel therapeutic agents targeting migraine and other neurological disorders. It is primarily utilized by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and academic research institutions focused on neuropharmacology and drug discovery.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of next-generation triptan-class migraine medications.
• Neurological Research: Used as a reference standard and active compound in preclinical studies investigating serotonin receptor mechanisms and migraine pathophysiology.
• Drug Discovery & Development: Employed in high-throughput screening (HTS) and structure-activity relationship (SAR) studies to develop new central nervous system (CNS) active drugs.
• Contract Manufacturing: Supplied to CMOs and API manufacturers for scale-up synthesis under cGMP conditions for clinical trial material production.
• Academic Research: Utilized in university and institutional labs for pharmacological studies and teaching purposes related to neurochemistry.

Basic Information

Product Name	Donitriptan
CAS No.	170911-68-9
Molecular Formula	C17H25N3O2S
Molecular Weight	335.47 g/mol
Synonyms	N-[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]-N-methyl-methanesulfonamide; Donitriptan Hydrochloride (common salt form); 5-[[Methyl(methylsulfonyl)amino]methyl]-3-(2-dimethylaminoethyl)indole; BMS-180048; ATC code N02CC07 (where applicable)
EINECS	Contact for details

Quality Control

Our Donitriptan is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to industry best practices and can support development projects requiring material manufactured under cGMP guidelines for preclinical and clinical use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.