Description

Ent-Frovatriptan is the enantiomer of the active pharmaceutical ingredient Frovatriptan, a selective serotonin receptor agonist. This high-purity compound is essential for pharmaceutical research and development, particularly in the study of stereochemistry and the development of enantiomerically pure therapeutics. It serves as a critical reference standard and starting material for analytical method development, process chemistry, and impurity profiling in the production of triptan-class migraine medications.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for quality control and analytical method validation in API manufacturing.
• Chiral Research & Development: Critical for stereochemical studies, enantiomeric excess determination, and the development of single-enantiomer drugs.
• Process Impurity Profiling: Employed to identify, quantify, and control the undesired enantiomer during the synthesis of Frovatriptan succinate.
• Metabolic and Pharmacological Studies: Utilized in preclinical research to understand the distinct biological activity and metabolic pathways of the enantiomer.
• Regulatory Compliance: Supports regulatory filings by providing a well-characterized impurity standard for ICH guideline compliance.

Basic Information

Product Name	Ent-Frovatriptan
CAS No.	158930-18-8
Molecular Formula	C14H17N3O
Molecular Weight	243.31 g/mol
Synonyms	(R)-Frovatriptan; (R)-N-[3-[3-(1-Methylpyrrolidin-2-yl)-1H-indol-5-yl]methyl]hydroxylamine; UNII-6K5VZ16J8T; Frovatriptan Enantiomer; Frovatriptan Impurity; (R)-Frovatriptan Free Base
EINECS	Contact for details

Quality Control

Our Ent-Frovatriptan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination by HPLC, to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and enantiomeric excess. We support compliance with ICH Q3A, Q3B, and Q6A guidelines for impurities and specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The material is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.