Description

Frovatriptan Succinate CAS NO 158930-09-7 is a high-purity active pharmaceutical ingredient (API) and a selective serotonin (5-HT1B/1D) receptor agonist. It is a critical component in the formulation of effective migraine-specific medications, offering a targeted therapeutic approach. This compound is essential for pharmaceutical manufacturers and research institutions engaged in the development and production of neurological treatments.

Application

• Pharmaceutical API: Primary active ingredient in the manufacture of oral tablets for the acute treatment of migraine headaches with or without aura.
• Neurological Research: Used as a reference standard and investigational compound in preclinical and clinical studies targeting 5-HT receptors.
• Drug Formulation Development: Serves as a key component in the R&D of new dosage forms, such as fast-dissolving tablets or other delivery systems.
• Analytical Standard: Employed as a high-purity standard in quality control laboratories for HPLC, LC-MS, and other analytical method development and validation.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of finished drug products.
• Generic Drug Production: A vital raw material for manufacturers producing bioequivalent generic versions of frovatriptan-based medications.

Basic Information

Product Name	Frovatriptan Succinate
CAS No.	158930-09-7
Molecular Formula	C20H29N3O7
Molecular Weight	423.47 g/mol
Synonyms	Frovatriptan succinate salt; (R)-Frovatriptan succinate; 6-Methylamino-6,7,8,9-tetrahydro-5H-carbazol-3-yl)-4-(1,2,4-triazol-1-ylmethyl)piperidine succinate; Frovatriptan hydrogen succinate; Frovatriptan (as succinate); Migard (brand name component); Allegro (brand name component); SB-209509/VL-769
EINECS	Contact for details

Quality Control

Our Frovatriptan Succinate is manufactured under strict quality management systems. Each batch is tested to ensure it meets stringent specifications for identity, purity, and potency, aligning with ICH guidelines. A comprehensive Certificate of Analysis (COA) detailing results for assay, related substances, residual solvents, and microbiological attributes is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Individual impurity: NMT 0.5% Total impurities: NMT 2.0%
Water Content (KF)	NMT 1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	NMT 20 ppm
Microbiological Enumeration	Complies with Ph. Eur. 2.6.12/2.6.13

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.