Description

Frovatriptan CAS NO 158747-02-5 is a selective serotonin (5-HT1B/1D) receptor agonist, belonging to the triptan class of pharmaceuticals. This compound is critical for the effective treatment of acute migraine headaches, offering patients a targeted therapeutic option. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of advanced neurological and cardiovascular medications.

Application

• Active Pharmaceutical Ingredient (API): Primary use in the formulation of prescription migraine medications.
• Neurological Research: Used as a reference standard in studies of serotonin receptor pathways and migraine pathophysiology.
• Pharmaceutical Development: Serves as a key intermediate in the R&D of new triptan-based therapies.
• Analytical Testing: Employed as a high-purity standard in HPLC and other chromatographic methods for quality control.
• Clinical Trial Materials: Supplied for use in bioequivalence studies and new drug application (NDA) submissions.
• Generic Drug Manufacturing: Essential for producing cost-effective generic versions of branded migraine treatments.

Basic Information

Product Name	Frovatriptan
CAS No.	158747-02-5
Molecular Formula	C14H17N3O
Molecular Weight	243.31 g/mol
Synonyms	Frovatriptan Succinate; (R)-Frovatriptan; Frovatriptan (base); 6-Methylamino-6,7,8,9-tetrahydro-5H-carbazole-3-carboxamide; SB-209509; FROVA (brand name); Migard; Almogran
EINECS	Contact for details

Quality Control

Our Frovatriptan is manufactured under strict quality management systems. Each batch is tested to meet or exceed relevant pharmacopeial standards (such as USP/EP monographs where applicable) for identity, purity, and potency. A comprehensive Certificate of Analysis (COA), detailing results for assay, related substances, residual solvents, and other critical parameters, is provided with every shipment to ensure full traceability and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Sulfated Ash	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.