Description

2-Butyl-4-Chloro-1-[(2'-(1-Triphenylmethyl-1H-Tetrazol-5-Yl)(1,1'-Biphenyl)-4-Yl)Methyl]Imidazole-5-Carboxylic Acid 1-[(Isopropoxy)Carbonyloxy]Methyl Ester is a sophisticated, high-purity pharmaceutical intermediate designed for advanced synthesis. This compound is critical for research and development in the life sciences sector, offering a key building block for complex molecular architectures. It is primarily utilized by pharmaceutical manufacturers and advanced research institutions engaged in the development of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in the sartan class of antihypertensive agents.
• Research & Development: Serves as a critical building block for medicinal chemists in drug discovery programs, enabling the exploration of new chemical entities.
• Process Chemistry: Used in the development and scale-up of manufacturing routes for target drug molecules under Good Manufacturing Practice (GMP) conditions.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.
• Chemical Synthesis: Utilized in advanced organic synthesis for constructing complex heterocyclic and biphenyl-containing structures.

Basic Information

Item	Detail
Product Name	2-Butyl-4-Chloro-1-[(2'-(1-Triphenylmethyl-1H-Tetrazol-5-Yl)(1,1'-Biphenyl)-4-Yl)Methyl]Imidazole-5-Carboxylic Acid 1-[(Isopropoxy)Carbonyloxy]Methyl Ester
CAS No.	947331-22-8
Molecular Formula	C48H43ClN6O5
Molecular Weight	819.35 g/mol
Synonyms	Olmesartan Medoxomil Trityl Ester; Olmesartan Medoxomil Trityl Protected Intermediate; 2-Butyl-4-chloro-1-[[2'-(1-trityl-1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid 1-[[(1-methylethoxy)carbonyl]oxy]methyl ester; 5-(2'-Trityl-2H-tetrazol-5-yl)-1-biphenyl-4-ylmethyl-2-butyl-4-chloro-1H-imidazole-3-carboxylic acid 1-isopropoxycarbonyloxymethyl ester; Trityl Olmesartan Medoxomil; RO 058-747 Trityl Ester
EINECS	Contact for details

Quality Control

Our 2-Butyl-4-Chloro-1-[(2'-(1-Triphenylmethyl-1H-Tetrazol-5-Yl)(1,1'-Biphenyl)-4-Yl)Methyl]Imidazole-5-Carboxylic Acid 1-[(Isopropoxy)Carbonyloxy]Methyl Ester is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed specifications are provided and can be tailored to meet specific client requirements for research or cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.