Description

Losartan Potassium is a potent and selective angiotensin II receptor antagonist (ARB) used as an active pharmaceutical ingredient (API). This compound is critical for the formulation of antihypertensive and cardioprotective medications, effectively managing high blood pressure and reducing the risk of stroke in patients with heart conditions. It is primarily required by pharmaceutical manufacturers and research institutions engaged in cardiovascular drug development and production.

Application

• Primary Active Pharmaceutical Ingredient (API) in antihypertensive medications.
• Formulation of combination drugs for cardiovascular disease management.
• Research and development of novel angiotensin II receptor blockers.
• Reference standard in analytical and quality control laboratories.
• Manufacturing of generic pharmaceutical products.
• Pre-clinical and clinical trial material for cardiovascular studies.

Basic Information

Item	Detail
Product Name	Losartan Potassium
CAS No.	12475-99-8
Molecular Formula	C22H22ClKN6O
Molecular Weight	461.01 g/mol
Synonyms	Losartan K; 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol monopotassium salt; Cozaar (Brand Name); DuP 753; MK-954; Potassium Losartan; (2-Butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanol potassium salt
EINECS	Contact for details

Quality Control

Our Losartan Potassium is manufactured under strict quality systems and undergoes rigorous analytical testing to ensure it meets the highest purity standards, including USP, EP, and ICH guidelines. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We are committed to providing materials suitable for GMP manufacturing and global regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.5% - 101.0% (on anhydrous basis)
Water Content (KF)	NMT 2.0%
Related Substances (HPLC)	Total impurities: NMT 1.0% Any individual impurity: NMT 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	NMT 20 ppm
Sulfated Ash	NMT 0.1%
pH (5% solution)	7.0 - 9.0

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.