Description

Moexiprilat Hydrate is the active diacid metabolite of the ACE inhibitor Moexipril. This high-purity reference standard and pharmaceutical intermediate is critical for analytical research, method development, and quality control in pharmaceutical manufacturing. It is primarily utilized by research institutions, analytical laboratories, and API producers focused on cardiovascular therapeutics.

Application

• Pharmaceutical Reference Standard: For the identification, assay, and impurity profiling of Moexipril and related drug products in compliance with pharmacopeial methods (USP, EP).
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a key synthetic precursor in the production of the prodrug Moexipril hydrochloride.
• Metabolite Studies: Essential for in-vitro and in-vivo pharmacokinetic and pharmacodynamic research to understand the drug's activity and clearance.
• Analytical Method Development: Used as a benchmark compound to develop and validate HPLC, LC-MS, and other chromatographic assays.
• Quality Control & Assurance: Employed in pharmaceutical QC labs to ensure the identity, strength, quality, and purity of finished drug products.
• Biochemical Research: Used in studies investigating angiotensin-converting enzyme (ACE) inhibition mechanisms and structure-activity relationships.

Basic Information

Product Name	Moexiprilat Hydrate
CAS No.	103775-14-0
Molecular Formula	C27H34N2O7 • xH2O
Molecular Weight	498.57 g/mol (anhydrous basis)
Synonyms	Moexipril Diacid; Moexiprilat; (3S)-2-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-3-isoquinolinecarboxylic Acid; RS-10085; UNII-6KQ7W5QJ7Q; Moexipril Acid; Moexipril Metabolite
EINECS	Contact for details

Quality Control

Our Moexiprilat Hydrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by IR and HPLC, assay determination, and control of specified impurities. A Certificate of Analysis (COA) detailing purity, residual solvents, and other critical parameters is provided with every shipment to ensure traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Water Content (KF)	≤5.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.