Description

Benazepril is a potent, long-acting angiotensin-converting enzyme (ACE) inhibitor used as an active pharmaceutical ingredient (API). It is a critical component in the formulation of antihypertensive and heart failure medications, valued for its efficacy and favorable pharmacokinetic profile. This high-purity compound is essential for pharmaceutical manufacturers and research institutions developing cardiovascular therapies. Benazepril CAS NO 109010-10-8 is supplied under stringent quality controls to meet the exacting standards of the global pharmaceutical industry.

Application

Benazepril is primarily utilized in the following applications:

• Pharmaceutical API: As the active ingredient in prescription medications for the treatment of hypertension (high blood pressure).
• Cardiovascular Drug Formulation: Used in the development and production of tablets, capsules, and other dosage forms for managing heart failure.
• Research & Development: Serves as a key reference standard and intermediate in pharmacological studies and the development of new cardiovascular agents.
• Generic Drug Manufacturing: A vital component for companies producing generic versions of ACE inhibitor drugs.
• Veterinary Medicine: Occasionally formulated for use in treating hypertension in companion animals.

Basic Information

Product Name	Benazepril
CAS No.	109010-10-8
Molecular Formula	C24H28N2O5•HCl
Molecular Weight	460.95 g/mol (Hydrochloride salt)
Synonyms	Benazepril Hydrochloride; CGS-14824A; CGS 14824; (3S)-3-[[(1S)-1-Ethoxycarbonyl-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid hydrochloride; Benzazepril; Lotensin (Brand Name)
EINECS	Contact for details

Quality Control

Our Benazepril is manufactured and tested to meet the highest purity standards required for pharmaceutical applications. Quality is assured through a comprehensive battery of analytical tests, including HPLC, IR, and loss on drying. We adhere to cGMP (current Good Manufacturing Practice) guidelines, and a detailed Certificate of Analysis (COA) is provided with each batch to confirm compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Specific Rotation	-165° to -175° (c=1 in methanol)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.