Description

Zofenopril Calcium is the calcium salt of the active metabolite of the prodrug zofenopril, functioning as a potent and long-acting angiotensin-converting enzyme (ACE) inhibitor. This compound is of paramount importance in the pharmaceutical industry for the development and production of cardiovascular medications. It is primarily required by manufacturers of active pharmaceutical ingredients (APIs), generic drug producers, and research institutions focused on hypertension and heart failure therapeutics. Zofenopril Calcium CAS NO 81938-43-4 offers a critical building block for creating effective treatments that manage blood pressure and improve cardiac function.

Application

• Active Pharmaceutical Ingredient (API): Primary use in the formulation of finished dosage forms for antihypertensive and heart failure drugs.
• Generic Drug Manufacturing: Serves as a key intermediate for companies producing generic versions of ACE inhibitor medications.
• Pharmaceutical Research & Development: Utilized in preclinical and clinical studies for investigating new cardiovascular therapies and combination treatments.
• Reference Standard: Employed as a high-purity standard in analytical laboratories for quality control and method validation.
• Chemical Synthesis: Acts as a crucial intermediate for the synthesis of more complex pharmaceutical molecules within the same therapeutic class.

Basic Information

Product Name	Zofenopril Calcium
CAS No.	81938-43-4
Molecular Formula	C22H30CaN2O6S2
Molecular Weight	530.70 g/mol
Synonyms	Zofenopril Calcium Salt; (4S)-1-[(2S)-3-(Benzoylthio)-2-methylpropanoyl]-4-(phenylthio)-L-proline Calcium Salt; SQ 26,991; SQ-26991; Zofenoprilat Calcium; Zofenil Calcium; Bifril Calcium; Zopranol Calcium
EINECS	Contact for details

Quality Control

Our Zofenopril Calcium is manufactured under strict quality management systems to ensure it meets the rigorous standards required for pharmaceutical applications. Each batch is subjected to comprehensive analytical testing, including identification, assay, and impurity profiling via techniques such as HPLC, IR, and titration. We provide full traceability and support regulatory submissions. Certificates of Analysis (COA) documenting compliance with in-house specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive (store away from light); therefore, containers must be kept tightly sealed and opened under low-humidity conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.