Description

Trandolapril is a potent, long-acting angiotensin-converting enzyme (ACE) inhibitor used in the management of hypertension and heart failure. Its primary value lies in its proven efficacy for cardiovascular protection and its favorable pharmacokinetic profile, offering sustained therapeutic action. This active pharmaceutical ingredient (API) is essential for pharmaceutical manufacturers developing high-quality generic and branded antihypertensive medications. Trandolapril CAS NO 87679-37-6 is supplied to meet the stringent requirements of the global pharmaceutical industry.

Application

• Pharmaceutical API: Primary use as the active ingredient in finished dosage forms for the treatment of hypertension.
• Cardiovascular Drug Formulations: Manufacture of tablets and capsules indicated for heart failure and post-myocardial infarction management.
• Fixed-Dose Combination Drugs: Used in combination with other antihypertensive agents like calcium channel blockers (e.g., Verapamil) for enhanced therapeutic effect.
• Generic Drug Production: Sourcing of high-purity trandolapril for cost-effective generic pharmaceutical development and manufacturing.
• Clinical Research Materials: Supply of certified material for bioequivalence studies and new drug formulation research.
• Reference Standard: Potential use as a high-purity chemical reference standard in analytical laboratories for quality control testing.

Basic Information

Product Name	Trandolapril
CAS No.	87679-37-6
Molecular Formula	C24H34N2O5
Molecular Weight	430.54 g/mol
Synonyms	(2S,3aR,7aS)-1-[(2S)-2-[[(1S)-1-Ethoxycarbonyl-3-phenylpropyl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid; Trandolaprilum; Gopten; Mavik; Odrik; RU 44570
EINECS	Contact for details

Quality Control

Our Trandolapril is manufactured under strict quality management systems to ensure it meets the highest standards for pharmaceutical use. Each batch is tested against rigorous specifications, including identity, purity, and impurity profiles, aligning with major pharmacopoeial guidelines such as USP and EP. A comprehensive Certificate of Analysis (COA) documenting all test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.