Description

Cilazapril CAS NO 104013-57-2 is an angiotensin-converting enzyme (ACE) inhibitor belonging to the class of prodrugs, which is metabolized in the body to its active diacid form, cilazaprilat. This compound is of significant commercial importance as a key active pharmaceutical ingredient (API) used in the formulation of antihypertensive and heart failure medications. It is primarily required by pharmaceutical manufacturers, research institutions, and contract development and manufacturing organizations (CDMOs) involved in cardiovascular drug production.

Application

• Pharmaceutical API: Primary use as the active ingredient in prescription medications for the treatment of hypertension (high blood pressure).
• Cardiovascular Therapeutics: Formulation into drugs for managing congestive heart failure and improving survival post-myocardial infarction.
• Clinical Research: Serves as a reference standard and raw material in pharmacokinetic and pharmacodynamic studies.
• Generic Drug Manufacturing: Essential for companies producing bioequivalent versions of branded cilazapril-based drugs.
• Preclinical Development: Used in animal studies to investigate new indications or combination therapies for cardiovascular diseases.
• Analytical Testing: Employed as a high-purity standard in quality control laboratories for HPLC and other assay methods.

Basic Information

Product Name	Cilazapril
CAS No.	104013-57-2
Molecular Formula	C22H31N3O5
Molecular Weight	417.50 g/mol
Synonyms	Ro 31-2848; Cilazaprilum; Cilazapril (USAN); (1S,9S)-9-[[(1S)-1-Carboxy-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid; 1H-Pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid, 9-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-, (1S,9S)-; Inhibace (Trade Name); Vascace (Trade Name)
EINECS	Contact for details

Quality Control

Our Cilazapril is manufactured under strict quality management systems, targeting specifications suitable for pharmaceutical applications. Each batch undergoes comprehensive analytical testing, including identification, assay, and impurity profiling via HPLC, to ensure compliance with pharmaceutical-grade standards. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity (>98.5% typical), and limits for related substances.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.5% - 101.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 1.0%; Any single impurity ≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.