Description

Carboxylicacidphenylmethylesterhydrochloride,Quinaprilhcl CAS NO 103733-30-8 is the hydrochloride salt form of a key pharmaceutical intermediate, specifically associated with the synthesis of Quinapril. This compound is critical for ensuring the purity, stability, and consistent performance of the final active pharmaceutical ingredient (API). It is primarily required by manufacturers in the pharmaceutical and fine chemical industries engaged in the production of cardiovascular medications and advanced chemical research.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of the antihypertensive drug Quinapril, an angiotensin-converting enzyme (ACE) inhibitor.
• Active Pharmaceutical Ingredient (API) Manufacturing: Serves as a direct precursor in the final stages of API production under controlled Good Manufacturing Practice (GMP) environments.
• Research & Development: Used in pharmaceutical R&D laboratories for process development, optimization, and the creation of novel derivative compounds.
• Reference Standard: Employed as a high-purity analytical standard for quality control testing, method validation, and regulatory submissions.
• Fine Chemical Synthesis: Utilized in specialized organic synthesis for constructing complex molecules with specific carboxylic acid ester functionalities.

Basic Information

Product Name	Carboxylicacidphenylmethylesterhydrochloride,Quinaprilhcl CAS NO 103733-30-8
CAS No.	103733-30-8
Molecular Formula	C25H30N2O5•HCl
Molecular Weight	474.98 g/mol
Synonyms	Quinapril Hydrochloride; (3S)-2-[(2S)-2-[[(1S)-1-Carboxy-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid, 1-ethyl ester, hydrochloride; Quinapril HCl; Quinaprilat Ethyl Ester Hydrochloride; CI-906; Accupril Intermediate; S-8308 Hydrochloride
EINECS	Contact for details

Quality Control

Our Quinapril Hydrochloride intermediate is manufactured with a focus on high purity and consistency, adhering to stringent quality protocols suitable for pharmaceutical applications. Quality is verified through comprehensive analytical testing including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each batch. Production can be aligned with GMP guidelines upon request to meet specific regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Maximum Unknown Impurity	≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.