Description

(1S, 9S)-9-[[(R)-1-Ethoxycarbonyl-3-Phenylpropyl] Amino]-10-Oxo-Octahydro-6H-Pyridazino [1,2-A][1,2] Diazepine-1-Carboxylic Acid is a high-purity, non-peptidic intermediate of significant importance in advanced pharmaceutical synthesis. This compound matters because it serves as a critical chiral building block for the development of novel enzyme inhibitors, particularly in cardiovascular and metabolic disease research. Pharmaceutical R&D teams and fine chemical manufacturers need this material for its precise stereochemistry and role in constructing complex molecular architectures with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for hypertension and heart failure treatments.
• Enzyme Inhibitor Synthesis: Used as a core structural component in the synthesis of non-peptidic inhibitors targeting metalloproteases like neprilysin (NEP).
• Cardiovascular Drug Research: Integral to the discovery and process chemistry of next-generation vasopeptidase inhibitors and combination therapies.
• Process Development & Scale-Up: Employed in optimizing synthetic routes from laboratory scale to pilot plant and commercial manufacturing.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory submissions in pharmaceutical production.
• Academic & Contract Research: Utilized in university and CRO settings for medicinal chemistry programs and structure-activity relationship (SAR) studies.

Basic Information

Product Name	(1S, 9S)-9-[[(R)-1-Ethoxycarbonyl-3-Phenylpropyl] Amino]-10-Oxo-Octahydro-6H-Pyridazino [1,2-A][1,2] Diazepine-1-Carboxylic Acid
CAS No.	106928-09-0
Molecular Formula	C24H32N4O5
Molecular Weight	456.54 g/mol
Synonyms	(1S,9S)-9-{[(2R)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-10-oxooctahydro-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid; (S,S,R)-AHU-377 Impurity; Sacubitril Intermediate; LCZ696 Intermediate; LBQ657 Impurity; Neprilysin Inhibitor Intermediate; Entresto® (Sacubitril/Valsartan) Related Compound; UNII-8WZ5SOJ5L8
EINECS	Contact for details

Quality Control

Our (1S, 9S)-9-[[(R)-1-Ethoxycarbonyl-3-Phenylpropyl] Amino]-10-Oxo-Octahydro-6H-Pyridazino [1,2-A][1,2] Diazepine-1-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and identity confirmation by spectroscopic methods, to ensure compliance with pharmaceutical intermediate standards. Comprehensive Certificates of Analysis (COA) detailing purity, impurities, and residual solvents are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.