Description

Fosinopril CAS NO 98048-97-6 is a potent, phosphonate-containing angiotensin-converting enzyme (ACE) inhibitor used as an active pharmaceutical ingredient (API). It is a critical compound for the development and manufacturing of antihypertensive and heart failure medications. This high-purity chemical is essential for pharmaceutical manufacturers, research institutions, and contract development and manufacturing organizations (CDMOs) engaged in cardiovascular drug production.

Application

• Pharmaceutical API Manufacturing: Primary use as the active ingredient in finished dosage forms for treating hypertension and congestive heart failure.
• Generic Drug Formulation: Serves as a key component in the production of generic versions of ACE inhibitor medications.
• Clinical Research & Development: Utilized in preclinical and clinical studies for developing new cardiovascular therapies or combination drugs.
• Reference Standard: Acts as a high-purity standard for quality control and analytical method development in pharmaceutical laboratories.
• Bulk Pharmaceutical Intermediates: May be used in the synthesis of related pharmaceutical compounds or prodrugs.

Basic Information

Product Name	Fosinopril
CAS No.	98048-97-6
Molecular Formula	C30H46NO7P
Molecular Weight	563.66 g/mol
Synonyms	Fosinopril Sodium; SQ 28555; Fosinoprilum; (2S,4S)-4-Cyclohexyl-1-[2-[[(1S)-1-carboxy-3-phenylpropyl]amino]-1-oxopropyl]-2-methyl-2,3-dihydro-1H-isoindole-7-carboxylic acid 1-ethyl ester 4-oxide; Phosphinic acid, P-[[1-[[(2S)-1-ethoxy-1-oxo-4-phenyl-2-[(phosphinyloxy)methyl]butyl]amino]cyclopentyl]carbonyl]-, (4S)-; Monopril (brand name); Staril (brand name); ACE Inhibitor SQ 28555
EINECS	Contact for details

Quality Control

Our Fosinopril is manufactured under strict quality management systems to ensure it meets the rigorous standards required for pharmaceutical applications. Each batch is tested against comprehensive specifications, including identity, purity, and impurity profiles, typically referencing USP/EP monographs. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a low-humidity environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC)	98.0% - 102.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Water (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.