Description

Orbutopril is a synthetic organic compound belonging to the class of ACE inhibitors, primarily utilized as a key pharmaceutical intermediate. Its significance lies in its role in the synthesis of active pharmaceutical ingredients (APIs) for cardiovascular medications, ensuring high-purity input for critical drug manufacturing processes. This product is essential for research institutions, pharmaceutical development laboratories, and large-scale API producers requiring reliable, high-quality building blocks for antihypertensive therapies.

Application

• Pharmaceutical Intermediate: Primary use as a critical building block in the synthesis of Angiotensin-Converting Enzyme (ACE) inhibitor active pharmaceutical ingredients (APIs).
• Cardiovascular Drug Research: Used in preclinical and clinical research for developing new antihypertensive and heart failure medications.
• Process Chemistry & Scale-Up: Employed in process optimization and scale-up studies for the commercial manufacturing of finished dosage forms.
• Reference Standard: Serves as a high-purity chemical reference standard for analytical method development and quality control in pharmaceutical labs.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of generic and proprietary drugs.

Basic Information

Product Name	Orbutopril
CAS No.	108391-88-4
Molecular Formula	C15H20N2O5S
Molecular Weight	340.40 g/mol
Synonyms	N-[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl-L-proline; (S)-1-[(S)-3-Benzyl-2-[(S)-1-ethoxy-1-oxopropan-2-ylamino]propanoyl]pyrrolidine-2-carboxylic acid; Orbutopril; SQ 26,991; SQ-26991; SQ26991; L-Alanine, N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]-L-prolyl-; ACE Inhibitor Intermediate
EINECS	Contact for details

Quality Control

Our Orbutopril is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral purity determination, and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. Our quality commitment aligns with cGMP principles to support our clients' regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.