Description

Captopril CAS NO 62571-86-2 is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE). This small-molecule active pharmaceutical ingredient (API) is critical for the formulation of antihypertensive and heart failure medications. It is primarily required by pharmaceutical manufacturers and research institutions for the production of generic and branded cardiovascular drugs, as well as for advanced clinical research.

Application

• Pharmaceutical API: Primary use in the manufacture of oral solid dosage forms (tablets) for the treatment of hypertension (high blood pressure).
• Cardiovascular Therapeutics: Essential component in medications for congestive heart failure and for improving survival post-myocardial infarction.
• Research & Development: Used as a reference standard in analytical laboratories for method development and validation (HPLC, spectroscopy).
• Clinical Studies: Serves as the active ingredient in clinical trial materials for new drug formulations or combination therapies.
• Veterinary Medicine: Applied in veterinary pharmaceuticals for managing hypertension in companion animals.
• Biochemical Research: Utilized as a specific ACE inhibitor in biochemical assays and pharmacological studies to understand the renin-angiotensin system.

Basic Information

Product Name	Captopril
CAS No.	62571-86-2
Molecular Formula	C9H15NO3S
Molecular Weight	217.29 g/mol
Synonyms	L-Captopril; (2S)-1-[(2S)-2-Methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid; SQ 14,225; Capoten® (brand name); ACE Inhibitor; 3-Mercapto-2-methylpropanoyl-L-proline; L-2-Methyl-3-mercaptopropanoyl-L-proline
EINECS	263-607-1

Quality Control

Our Captopril is manufactured under strict quality management systems. It is typically supplied meeting USP/EP/BP monograph specifications, ensuring suitability for pharmaceutical applications. Each batch undergoes comprehensive analytical testing, including assay, impurity profiling, and residual solvent analysis. A Certificate of Analysis (COA) documenting purity, identity, and compliance is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store under an inert atmosphere for long-term stability. Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Specific Rotation	-126° to -132° (c = 2, in ethanol)
Related Substances (HPLC)	Total impurities ≤ 2.0% Individual unknown impurity ≤ 0.5% Captopril Disulfide ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Sulfate Ash	≤ 0.2%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.