Description

Palonidipine is a high-purity pharmaceutical intermediate and active pharmaceutical ingredient (API) belonging to the dihydropyridine class of calcium channel blockers. This compound is critical for the research, development, and production of advanced cardiovascular therapeutics. It is primarily utilized by pharmaceutical manufacturers, R&D laboratories, and fine chemical suppliers serving the global healthcare sector.

Application

• Pharmaceutical API Synthesis: Serves as the key active ingredient in the formulation of antihypertensive medications.
• Cardiovascular Drug Development: Used in preclinical and clinical research for developing new calcium channel blockers.
• Reference Standard: Employed as a high-purity analytical standard in quality control (QC) and quality assurance (QA) laboratories.
• Biochemical Research: Utilized in pharmacological studies to investigate calcium ion channel mechanisms and vascular physiology.
• Fine Chemical Intermediate: Acts as a critical building block for the synthesis of more complex pharmaceutical molecules.
• Generic Drug Manufacturing: Essential for the production of generic versions of palonidipine-based medications.

Basic Information

Product Name	Palonidipine
CAS No.	96515-73-0
Molecular Formula	C27H29N3O7
Molecular Weight	507.54 g/mol
Synonyms	Palonidipine; 3-O-ethyl 5-O-methyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; CS-905; (±)-Palonidipine; (±)-3-O-Ethyl 5-O-methyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; Palonidipinum; Palonidipino; UNII-8V6T7LFM8P
EINECS	Contact for details

Quality Control

Our Palonidipine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by IR and NMR, to ensure it meets stringent pharmaceutical-grade specifications. A Certificate of Analysis (COA) documenting full compliance is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light yellow crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time conforms to reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5% Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.